Photobiomodulation Therapy for Dry Age-Related Macular Degeneration (AMD)

 

What is Photobiomodulation (PBM)?

Photobiomodulation (PBM) is a non-invasive therapy that uses specific wavelengths of light (590, 660, and 850 nanometers) to stimulate cellular activity in the retina. The goal is to enhance mitochondrial function, reduce inflammation, and support retinal health, potentially slowing the progression of dry AMD.​

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The Valeda® Light Delivery System

The Valeda® system delivers multiwavelength PBM therapy directly to the retina. Treatment involves nine sessions over 3 to 5 weeks, repeated every four months. Each session is quick and painless, performed in a clinical setting.

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Clinical Evidence: LIGHTSITE Trials

LIGHTSITE III Trial

• Design: A randomized, double-masked, sham-controlled trial involving 100 participants (148 eyes) with intermediate dry AMD.

• Duration: 24 months, with key findings reported at 13 and 24 months.

• Results at 13 Months:

  • Visual Acuity: PBM-treated eyes showed a mean improvement of 5.4 letters in best-corrected visual acuity (BCVA), compared to 3.0 letters in the sham group.

  • Geographic Atrophy (GA): A significant reduction in new-onset GA was observed in the PBM group (P = 0.024).

  • Safety: PBM was well-tolerated with a favorable safety profile. ​

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LIGHTSITE II Trial

• Design: A multicenter, randomized, sham-controlled trial assessing the impact of PBM over 10 months.

• Findings:

  • Visual Function: Improvements in BCVA and contrast sensitivity were noted in PBM-treated participants.

  • Anatomical Changes: Stabilization or reduction in drusen volume and thickness, markers associated with AMD progression.

  • Quality of Life: Participants reported enhanced visual function and daily living activities.​

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Conclusion

PBM therapy using the Valeda® system has demonstrated potential benefits in improving visual function and slowing disease progression in intermediate dry AMD. While results are promising, further research is ongoing to confirm long-term efficacy and optimal treatment protocols.​

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For personalized advice and to determine if PBM therapy is suitable for you, please consult your eye care professional.